Telomerase immortalization of principal cells from mouse collecting duct
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چکیده
منابع مشابه
Telomerase immortalization of principal cells from mouse collecting duct.
Recently, the use of overexpression of telomerase reverse transcriptase (TERT) has led to the generation of immortalized human cell lines. However, this cell immortalization approach has not been reported in well-differentiated mouse cells, such as renal epithelial cells. We sought to establish and then characterize a mouse collecting duct cell line, using ectopic expression of mTERT. Isolated ...
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1 2 August 3, 2012 3 Revised: August 6, 2012 4 5 Quantitative Phosphoproteomics in Nuclei of Vasopressin-Sensitive 6 Renal Collecting Duct Cells 7 8 9 Steven J. Bolger*, Patricia A. Gonzales Hurtado*, Jason D. Hoffert, Fahad Saeed, Trairak 10 Pisitkun, and Mark A. Knepper 11 12 *Co-First Authors 13 14 Epithelial Systems Biology Laboratory, 15 NHLBI, National Institutes of Health, 16 Bethesda, M...
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The main feature of polycystic kidney diseases (PKD) is formation and progressive enlargement of renal cysts. Alterations in epithelial cell proliferation, extracellular matrix, and ion transport are thought to contribute to cyst enlargement and loss of renal function. Abnormal Cl- secretion is implicated in cyst enlargement in autosomal dominant PKD (ADPKD), but little is known about transport...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2010
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00183.2010